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Nuclear signaling


Nuclear signaling events typically result in the generation of a huge and relatively stable complex composed of a functional transcriptional activator protein, additional proteins that bind to the activator protein, and the RNA polymerase and associated proteins bound at the start site of transcription. Most of the relevant signaling events act to “seed” this complex by generating an active transcriptional activator protein by phosphorylation, by inducing a conformational change in the activator upon ligand binding, by fostering nuclear localization, by removing an inhibitor, or simply by making more activator protein. Creative Biomart provides useful tools for you to study nuclear signaling pathways.

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