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Protein receptor tyrosine kinases (RTKs) are transmembrane-spanning receptors located in the cell membrane that have an intrinsic protein tyrosine kinase activity that is normally dependent on binding of the cognate ligand. There are 58 known RTKs distributed within 20 different families. Each member has a specific biological function; however the different families of RTKs are morphologically related and share a common structure consisting of a large ligand-binding extracellular domain, a lipophilic transmembrane spanning region, and a cytoplasmic domain.

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