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human FADD


The apoptosis-signaling adaptor molecule (FADD) plays multiple roles in the immune system. Although FADD was initially characterized for its critical role in mediating apoptotic signals from the DRs, it has since become obvious that FADD is not a functionally one-dimensional molecule. FADD has been implicated in innate immune responses, proliferation and/or cell cycle regulation of lymphoid and nonlymphoid cells, and necroptotic and autophagic signaling. Therefore, it appears FADD is a multifunctional protein that has various roles that may or may not be dependent on its interaction with the death receptors.

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