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growth factor


Growth factors play important roles in both positively and negatively regulating proliferation of a variety of cell types in tissue growth, differentiation, and tumorigenesis. It is thought that growth factors have an important central function in mitosis and cell differentiation because growth factors have been found in the three trophoblastic forms in immunohistochemical analyses. Moreover, an autocrine and paracrine function has been suggested in the regulation of the implantation of the blastocyst, owing to the presence of common receptors found in the human endometrium, decidual and implantation zones. Growth factors have a physiological role in fetal growth.

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