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staphylococcal nuclease


Staphylococcal nuclease, also known as micrococcal nuclease, is an extracellular endo-exonuclease of Staphylococcus aureus that preferentially digests single-stranded nucleic acids. It is a small protein composed of 149 amino acid residues formed a no intrachain crosslinkages single peptide chain with molecular weight of 16.9kDa. The relevant 3D structure analysis of staphylococcal nuclease has indicated the molecule has three long α helices and a five-stranded, barrel-shaped β sheet which arranged as oligonucleotide-binding fold. Additionally, there is a prominently exposed loop on the surface of staphylococcal nuclease, which plays an important role in affinity contact with binders.

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