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src homology 2


Src homology 2 (SH2) and Src homology 3 (SH3) are the two noncatalytic domains of Src family tyrosine kinases which has similar structural arrangement. SH2 is approximately 100 amino acids long domain contains two α helices and seven β strands. As well as SH3, a smaller domain of about 60 amino acids residues, characterized by a β-barrel fold consists of five or six β-strands arranged as two tightly packed anti-parallel β sheets, short helices may be contained at the linker regions. Both SH2 and SH3 can be found in a variety of signaling molecules, owning to the role of them in kinase regulation, SH2 and SH3 and their ligands have become important signal transduction targets for drug discovery.

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