Directory >

next generation car t


A chimeric antigen receptor (CAR) mainly consists of a single chain variable fragment (scFv) from a mAb, an extracellular hinge and spacer element, a transmembrane region (TM) and an internal signaling domain such as CD3ζ or Fc receptor γ cytoplasmic signaling domains (FcεRIγ). The main advantage of CAR modified T cell is that it decreases MHC restriction, which allows the adoptive immune cells to be directly activated in various types of cancers.

There are no comments yet. Be the first to comment

Read Next