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tgf beta information


Transforming growth factors” (TGFs) superfamily members are responsible for causing normal fibroblasts to undergo anchorage-independent growth, a property closely associated with the transformed, or malignant, phenotype in vivo. TGF-α is originally thought to be expressed solely by tumor cells, and TGF-β is thought to be expressed in normal tissues and served to modulate the transforming process. TGF-β1 was found and charactered in the early 1980’s and this leads to the identification of two TGF-β isoforms (TGF-β2, TGF-β3) and a large family of growth factors that are essential regulators of developmental processes, physiology and disease pathogenesis.

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